Dr. Wise was born in Cincinnati, Ohio but grew up in Atlanta, Georgia. He made the circle back to the Midwest when he joined Allergy Associates, later to become Allergy Partners of Central Indiana, in 1991.

After over two decades of doctoring, Dr. Wise remains enthusiastic in the practice of Allergy. “I believe that educating patients and patient input are important parts of medical care. By listening to patients and families, I work with them to develop an individualized treatment plan.”

Dr. Wise cares for patients of all ages for a range of allergic diseases, but is particularly drawn to the areas of nasal (allergic rhinitis/ hay fever) and sinus issues, asthma, and food allergy. These are areas in which good care can greatly improve quality of life. Dr. Wise is a strong supporter of allergen immunotherapy, or “allergy injections”, as one of the few treatments in medicine with a true disease modifying and curative potential. He takes great pride in his work and has been voted a “Top Doctor in Allergy/Immunology” in Indianapolis Monthly Magazine’s physician’s survey every year since 2013.

Dr. Wise also enjoys teaching and has received the American College of Physicians Preceptorship Award for outstanding community based education. He is a past President of the Indiana Allergy, Asthma, and Immunology Society, and is involved in training medical students and residents as an assistant Clinical Professor of Medicine and volunteer faculty at both the Indiana University Medical Center and the newer Marion University College of Osteopathic Medicine.

“But mainly, I’m a nice guy!”

Medical School

Internship

Residency

Fellowship

Board Certified

Dr. Epstein is board certified in Adult and Pediatric Allergy & Immunology, and has been in clinical practice since 2010. She is an Assistant Professor of Medicine at the University of Cincinnati and Marian University. She has been the principal investigator on research grants sponsored by the National Institutes of Health, and has served as an key investigator on the safety of allergen vaccines for the past 7 years.

Dr. Epstein completed her fellowship training in Adult and Pediatric Allergy & Immunology at the University of Cincinnati and Cincinnati Children’s Hospital. She completed her residency in Internal Medicine at Washington University in St. Louis, and earned her medical and undergraduate degrees from Indiana University with majors in Biology and Spanish.

“My clinical interests include a broad range of allergic and immunologic diseases, including asthma, rhinitis, drug allergy, immune deficiencies, and allergic skin disorders.”

Given her expertise, she serves on several national committees for the American Academy of Allergy, Asthma & Immunology. She has published works related to ensuring the safety of allergen vaccines, childhood exposures and the development of allergies, the treatment of angioedema, and the management of asthma.

“My husband and I, and our three children are delighted to be returning to our Indianapolis roots.”

Textbook:

Treatment of Asthma in Older Adults: A Comprehensive, Evidence-Based Guide

by Tolly E. G. Epstein and Sharmilee M. Nyenhuis.  Published by Springer, 2019

Articles: https://www.ncbi.nlm.nih.gov/pubmed/?term=tolly+epstein

[ ]1.AAAAI/ACAAI Subcutaneous Immunotherapy Surveillance Study (2013-2017): Fatalities, Infections, Delayed Reactions, and Use of Epinephrine Autoinjectors.

Epstein TG, Liss GM, Berendts KM, Bernstein DI.

J Allergy Clin Immunol Pract. 2019 Jul – Aug;7(6):1996-2003.e1. doi: 10.1016/j.jaip.2019.01.058. Epub 2019 Feb 15.

PMID:

30776526

[ ]2.Are Allergen Immunotherapy Dose Adjustments Needed for Local Reactions, Peaks of Season, or Gaps in Treatment?

Epstein TE, Tankersley MS.

J Allergy Clin Immunol Pract. 2017 Sep – Oct;5(5):1227-1233. doi: 10.1016/j.jaip.2017.04.022. Epub 2017 Jul 12. Review. No abstract available.

PMID:

28709818

[ ]3.Evaluation of the risk of infection associated with subcutaneous allergen immunotherapy: American Academy of Allergy, Asthma, and Immunology and American College of Allergy, Asthma, and Immunology National Surveillance Study on Allergen Immunotherapy, 2014-2015.

Epstein TG, Liss GM, Murphy-Berendts K, Bernstein DI.

Ann Allergy Asthma Immunol. 2017 Apr;118(4):511-512. doi: 10.1016/j.anai.2017.01.012. Epub 2017 Mar 1. No abstract available.

PMID:

28259390

[ ]4.Current Evidence on Safety and Practical Considerations for Administration of Sublingual Allergen Immunotherapy (SLIT) in the United States.

Epstein TG, Calabria C, Cox LS, Dreborg S.

J Allergy Clin Immunol Pract. 2017 Jan – Feb;5(1):34-40.e2. doi: 10.1016/j.jaip.2016.09.017. Epub 2016 Nov 1. Review.

PMID:

27815065

[ ]5.Risk factors for fatal and nonfatal reactions to subcutaneous immunotherapy: National surveillance study on allergen immunotherapy (2008-2013).

Epstein TG, Liss GM, Murphy-Berendts K, Bernstein DI.

Ann Allergy Asthma Immunol. 2016 Apr;116(4):354-359.e2. doi: 10.1016/j.anai.2016.02.001. Epub 2016 Mar 3.

PMID:

26948485

[ ]6.Association of eosinophilic esophagitis and hypertrophic cardiomyopathy.

Davis BP, Epstein T, Kottyan L, Amin P, Martin LJ, Maddox A, Collins MH, Sherrill JD, Abonia JP, Rothenberg ME.

J Allergy Clin Immunol. 2016 Mar;137(3):934-6.e5. doi: 10.1016/j.jaci.2015.08.026. Epub 2015 Oct 5. Review. No abstract available.

PMID:

26441228

[ ]7.Significant predictors of poor quality of life in older asthmatics.

Kannan JA, Bernstein DI, Bernstein CK, Ryan PH, Bernstein JA, Villareal MS, Smith AM, Lenz PH, Epstein TG.

Ann Allergy Asthma Immunol. 2015 Sep;115(3):198-204. doi: 10.1016/j.anai.2015.06.021. Epub 2015 Jul 21.

PMID:

26208758

[ ]8.Optimum predictors of childhood asthma: persistent wheeze or the Asthma Predictive Index?

Amin P, Levin L, Epstein T, Ryan P, LeMasters G, Khurana Hershey G, Reponen T, Villareal M, Lockey J, Bernstein DI.

J Allergy Clin Immunol Pract. 2014 Nov-Dec;2(6):709-15. doi: 10.1016/j.jaip.2014.08.009. Epub 2014 Nov 6.

PMID:

25439361

[ ]9.AAAAI/ACAAI surveillance study of subcutaneous immunotherapy, years 2008-2012: an update on fatal and nonfatal systemic allergic reactions.

Epstein TG, Liss GM, Murphy-Berendts K, Bernstein DI.

J Allergy Clin Immunol Pract. 2014 Mar-Apr;2(2):161-7. doi: 10.1016/j.jaip.2014.01.004.

PMID:

24607043

[ ]10.Chronic traffic pollution exposure is associated with eosinophilic, but not neutrophilic inflammation in older adult asthmatics.

Epstein TG, Kesavalu B, Bernstein CK, Ryan PH, Bernstein JA, Zimmermann N, Lummus Z, Villareal MS, Smith AM, Lenz PH, Bernstein DI.

J Asthma. 2013 Nov;50(9):983-9. doi: 10.3109/02770903.2013.832293. Epub 2013 Oct 1.

PMID:

23931679

[ ]11.Immunotherapy safety: what have we learned from surveillance surveys?

Kannan JA, Epstein TG.

Curr Allergy Asthma Rep. 2013 Aug;13(4):381-8. doi: 10.1007/s11882-013-0353-0. Review.

PMID:

23636820

[ ]12.AAAAI and ACAAI surveillance study of subcutaneous immunotherapy, Year 3: what practices modify the risk of systemic reactions?

Epstein TG, Liss GM, Murphy-Berendts K, Bernstein DI.

Ann Allergy Asthma Immunol. 2013 Apr;110(4):274-8, 278.e1. doi: 10.1016/j.anai.2013.01.015. Epub 2013 Feb 21.

PMID:

23535092

[ ]13.Poor asthma control and exposure to traffic pollutants and obesity in older adults.

Epstein TG, Ryan PH, LeMasters GK, Bernstein CK, Levin LS, Bernstein JA, Villareal MS, Bernstein DI.

Ann Allergy Asthma Immunol. 2012 Jun;108(6):423-428.e2. doi: 10.1016/j.anai.2012.04.009. Epub 2012 May 1.

PMID:

22626595

[ ]14.Genetic variation in small proline rich protein 2B as a predictor for asthma among children with eczema.

Epstein TG, LeMasters GK, Bernstein DI, Ericksen MB, Martin LJ, Ryan PH, Biagini Myers JM, Butsch Kovacic MS, Lindsey MA, He H, Reponen T, Villareal MS, Lockey JE, Bernstein CK, Khurana Hershey GK.

Ann Allergy Asthma Immunol. 2012 Mar;108(3):145-50. doi: 10.1016/j.anai.2012.01.004.

PMID:

22374195

[ ]15.Immediate and delayed-onset systemic reactions after subcutaneous immunotherapy injections: ACAAI/AAAAI surveillance study of subcutaneous immunotherapy: year 2.

Epstein TG, Liss GM, Murphy-Berendts K, Bernstein DI.

Ann Allergy Asthma Immunol. 2011 Nov;107(5):426-431.e1. doi: 10.1016/j.anai.2011.05.020. Epub 2011 Jun 17.

PMID:

22018614

[ ]16.Systemic reactions to subcutaneous allergen immunotherapy.

Bernstein DI, Epstein T.

Immunol Allergy Clin North Am. 2011 May;31(2):241-9, viii-ix. doi: 10.1016/j.iac.2011.02.007. Review.

PMID:

21530817

[ ]17.Factors associated with severe versus mild immunotherapy-related systemic reactions: a case-referent study.

Liss GM, Murphy-Berendts K, Epstein T, Bernstein DI.

J Allergy Clin Immunol. 2011 May;127(5):1298-300. doi: 10.1016/j.jaci.2010.12.1086. Epub 2011 Feb 18. No abstract available.

PMID:

21315434

[ ]18.Opposing effects of cat and dog ownership and allergic sensitization on eczema in an atopic birth cohort.

Epstein TG, Bernstein DI, Levin L, Khurana Hershey GK, Ryan PH, Reponen T, Villareal M, Lockey JE, Lemasters GK.

J Pediatr. 2011 Feb;158(2):265-71.e1-5. doi: 10.1016/j.jpeds.2010.07.026.

PMID:

20884006

[ ]19.Surveillance of systemic reactions to subcutaneous immunotherapy injections: year 1 outcomes of the ACAAI and AAAAI collaborative study.

Bernstein DI, Epstein T, Murphy-Berendts K, Liss GM.

Ann Allergy Asthma Immunol. 2010 Jun;104(6):530-5. doi: 10.1016/j.anai.2010.04.008.

PMID:

20568387

[ ]20.Genetic and environmental risk factors for childhood eczema development and allergic sensitization in the CCAAPS cohort.

Biagini Myers JM, Wang N, LeMasters GK, Bernstein DI, Epstein TG, Lindsey MA, Ericksen MB, Chakraborty R, Ryan PH, Villareal MS, Burkle JW, Lockey JE, Reponen T, Khurana Hershey GK.

J Invest Dermatol. 2010 Feb;130(2):430-7. doi: 10.1038/jid.2009.300. Epub 2009 Sep 17.

PMID:

19759553

[ ]21.Current and emerging management options for hereditary angioedema in the US.

Epstein TG, Bernstein JA.

Drugs. 2008;68(18):2561-73. doi: 10.2165/0003495-200868180-00003. Review.

PMID:

19093699

Medical School

Residency

Fellowship

Board Certified

Professional Societies

L. Cheryl Puzio, MSN, APN, NP-C, CPNP-PC

Cheryl Puzio is board certified as a family practice nurse practitioner and as a pediatric nurse practitioner. She completed her pediatric nurse practitioner training at Indiana University, and her family practice NP training through the University of Massachusetts-Boston. She earned her undergraduate nursing degree at Indiana University, and holds a Bachelor of Science degree as chemistry major from the University of Michigan-Dearborn. She is a member of the American Academy of Allergy, Asthma and Immunology; the American Association of Nurse Practitioners; and the National Association of Pediatric Nurse Practitioners.

“I am privileged to collaborate with an exceptional group of physicians. I enjoy teaching patients about their illnesses, and working with them to maximize benefits of their plan of care.”

Cheryl enjoys reading, gardening, travel, scuba diving, and most importantly spending time with her family in her free time.

Steele Summers is a Board Certified Family Nurse Practitioner. She completed her graduate and undergraduate training at the University of Indianapolis. Steele is a member of the Coalition of Advanced Practice Nurses of Indiana (CAPNI), and the American Nursing Association (ANA).

“I feel fortunate to be able to work with a great group of physicians who strive to give their patients the best care possible. I enjoy providing care for the patients at Allergy Partners. “

Steele enjoys traveling (especially to Disney World), crafting, volunteering with church, and spending time with her family.